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- Title
Alterations in the Masseter Muscle and Plasma IL-6 Level Following Experimentally Induced Occlusal Interference and Chronic Stress -A Study in Rats.
- Authors
Simonić-Kocijan, Sunčana; Uhač, Ivone; Tariba, Petra; Fugošić, Vesna; Pavičić, Daniela Kovačević; Lajnert, Vlatka; Braut, Vedrana
- Abstract
This study was undertaken to examine the alteration of masseter and plasma interleukin-6 after inducing occlusal interference and chronic stress. Male Wistar rats were submitted to chronic stress pročedure, exposed to occlusal interference, or exposed to both mentioned pročedures. Whole blood and masseter tissue were collected to determine interleukin-6 level, measured by means of ELISA. Masseter pain was evaluated using the orofacial formalin test. Masseter interleukin-6 level was significantly higher in animals submitted to combination of occlusal interference and chronic stress than in the control group (p<0.05). There was positive and significant correlation between pain response and masseter interleukin-6 level (r=0.5741; p<0.0003). No significant differences in plasma interleukin-6 level were found between groups (p>0.05), as well as no correlation with pain (p>0.05). Combination of occlusal interference and chronic stress leads to strong local reaction characterized by high levels of masseter interleukine-6. High concentrations of muscle interleukin-6 and its correlation with pain point to inflammatory background of masticatory muscle pain.
- Subjects
MASSETER muscle; BLOOD plasma; INTERLEUKIN-6; CHRONIC diseases; PSYCHOLOGICAL stress; PAIN management; LABORATORY rats
- Publication
Collegium Antropologicum, 2012, Vol 36, Issue 2, p651
- ISSN
0350-6134
- Publication type
Article