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- Title
Analysis of the APOB Gene and Apolipoprotein B Serum Levels in a Mexican Population with Acute Coronary Syndrome: Association with the Single Nucleotide Variants rs1469513, rs673548, rs676210, and rs1042034.
- Authors
Aceves-Ramírez, Maricela; Valle, Yeminia; Casillas-Muñoz, Fidel; Martínez-Fernández, Diana Emilia; Parra-Reyna, Brenda; López-Moreno, Víctor Arturo; Flores-Salinas, Héctor Enrique; Valdés-Alvarado, Emmanuel; Muñoz-Valle, José Francisco; García-Garduño, Texali; Padilla-Gutiérrez, Jorge Ramón
- Abstract
Apolipoprotein B (APOB) is associated with the development of atherosclerosis and consequently in the acute coronary syndrome (ACS) physiopathology. Single number variants (SNVs) in apolipoprotein B gene (APOB) influence over the susceptibility for this syndrome. The aim of this study was to determine the impact of the rs1469513, rs673548, rs676210, and rs1042034 SNVs and serum levels of APOB in the risk of ACS in a population from western Mexico. We included 300 patients in the group of cases (ACSG) and 300 individuals in the control group (CG). APOB levels were evaluated by immunonephelometry, and SNVs were genotyped with TaqMan probes. We found significant allelic and genotypic differences between groups for rs673548 and rs676210 (OR = 1.33, p = 0.030 , OR = 2.69, p < 0.001) and rs1042034 (OR = 0.50, p = 0.037) SNVs. We found a risk haplotype TAGT (OR: 2.14, IC 1.50–3.04, p < 0.001). Our findings support a significant risk association between rs673548 and rs676210 variants for ACS; meanwhile, rs1042034 could be considered protective factor in a western Mexican population. Also, in this population, haplotype TAGT may confer 2.14 times a higher risk. APOB serum levels were compared by genotype variants in both groups without any significant statistical difference.
- Subjects
MEXICO; SINGLE nucleotide polymorphisms; APOLIPOPROTEIN B; ACUTE coronary syndrome; MEXICANS; HAPLOTYPES
- Publication
Genetics Research, 2022, p1
- ISSN
0016-6723
- Publication type
Article
- DOI
10.1155/2022/4901090