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- Title
Economic Burden of HIV Antiretroviral Therapy Adverse Events in the United States.
- Authors
Dekoven, Mitch; Makin, Charles; Marcus, Michael; Slaff, Samantha; Maiese, Eric M.
- Abstract
<bold>Objective: </bold>To estimate health care costs associated with medical events identified as antiretroviral therapy (ART)-attributable adverse events (AEs).<bold>Methods: </bold>During September 2006 to June 2012, adults with ≥1 HIV International Classification of Diseases, Ninth Revision, Clinical Modification diagnosis code (042/V08), ≥1 claim for ART prescription (March 2007-June 2011; index date), and continuous health plan enrollment for ≥6 months pre- and ≥12 months postindex were included (IMS' PharMetrics Plus Health Plan Claims Database). Patients with events of interest/ART claim during preindex period or with pregnancy/hepatitis C virus diagnosis/hepatitis B virus/cancer/tuberculosis during the study period were excluded. Postindex medical events were defined as first diagnosis code of event with ART claim ≤60 days prior to start of the event.<bold>Results: </bold>Differences in median total all-cause health care costs observed for diabetes/insulin resistance management (US$14,547 median all-cause health care costs during time periods identified as diabetes/insulin resistance medical events versus US$11,237 without diabetes/insulin resistance events; P=.0021), lipid disorders (US$12,825 versus US$10,033; P=.0004), and renal disorders (US$1389 versus US$0; P<.0001).<bold>Discussion/conclusion: </bold>Health care costs of ART AEs should be key consideration for payers/providers in HIV management.
- Subjects
UNITED States; ADVERSE health care events; ANTIRETROVIRAL agents; MEDICAL care costs; HIV infections; REGRESSION analysis; DATABASES; DRUG side effects; RETROSPECTIVE studies; CASE-control method; ANTI-HIV agents; ECONOMICS
- Publication
Journal of the International Association of Providers of AIDS Care, 2016, Vol 15, Issue 1, p66
- ISSN
2325-9582
- Publication type
journal article
- DOI
10.1177/2325957415594883