We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Investigations on the continuous flow generation of 2,6-dichloro-N-fluoropyridinium tetrafluoroborate using F<sub>2</sub> gas.
- Authors
Simon, Kevin; Znidar, Desiree; Glotz, Gabriel; Dallinger, Doris; Kappe, C. Oliver
- Abstract
An explorative study on the continuous flow generation of the N-F reagent 2,6-dichloro-1-fluoro-pyridinium tetrafluoroborate from 2-6-dichloropyridine and 10% F2/N2 and its telescoped downstream electrophilic fluorination reaction with an enamine is reported. The 2-step procedure was performed in a modular lab-scale silicon carbide flow reactor, which safely allowed processing corrosive F2 and precise temperature control. Both reaction sequences turned out to be very fast when carried out in flow at − 10 °C: the N-F generation step could be done within 7.9 s and only 6.6 s were necessary for the fluorination of the enamine.
- Subjects
TETRAFLUOROBORATES; ENAMINES; TEMPERATURE control; FLUORINATION; SILICON carbide; GASES
- Publication
Journal of Flow Chemistry, 2023, Vol 13, Issue 4, p427
- ISSN
2062-249X
- Publication type
Article
- DOI
10.1007/s41981-023-00291-z