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- Title
Discovery, Biosynthesis and Biological Activity of a Succinylated Myxochelin from the Myxobacterial Strain MSr12020.
- Authors
Okoth, Dorothy A.; Hug, Joachim J.; Garcia, Ronald; Müller, Rolf
- Abstract
Myxobacteria feature unique biological characteristics, including their capability to glide on the surface, undergo different multicellular developmental stages and produce structurally unique natural products such as the catecholate-type siderophores myxochelins A and B. Herein, we report the isolation, structure elucidation and a proposed biosynthesis of the new congener myxochelin B-succinate from the terrestrial myxobacterial strain MSr12020, featuring a succinyl decoration at its primary amine group. Myxochelin-B-succinate exhibited antibacterial growth inhibition and moderate cytotoxic activity against selected human cancer cell lines. This unique chemical modification of myxochelin B might provide interesting insights for future microbiological studies to understand the biological function and biosynthesis of secondary metabolite succinylation.
- Subjects
BIOSYNTHESIS; NATURAL products; MYXOBACTERALES; SIDEROPHORES; CELL lines; CANCER cells
- Publication
Microorganisms, 2022, Vol 10, Issue 10, p1959
- ISSN
2076-2607
- Publication type
Article
- DOI
10.3390/microorganisms10101959