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- Title
MiR-125a-5p Decreases the Sensitivity of Treg cells Toward IL-6-Mediated Conversion by Inhibiting IL-6R and STAT3 Expression.
- Authors
Li, Dan; Kong, Chao; Tsun, Andy; Chen, Chen; Song, Huihui; Shi, Guochao; Pan, Wen; Dai, Dai; Shen, Nan; Li, Bin
- Abstract
The transcription factor FOXP3 is essential for the differentiation and function of regulatory T cells (Treg). It is established that the transcription factor GATA-3 is induced in Treg cells under inflammatory conditions. GATA-3 stabilizes FOXP3 levels to avoid the differentiation of Treg cells into inflammatory-like T cells. The IL-6 signal pathway influences the sensitivity of Treg cells towards instability. The mechanism of GATA-3 in regulating FOXP3 and its relation to the IL-6 pathway remains unclear. Here we report how miR-125a-5p plays an important role in regulating the conversion of Treg cells by IL-6. miR-125a-5p expression is low in Treg cells under steady state conditions and can be induced by GATA-3 to inhibit the expression of IL-6R and STAT3. This finding reveals a GATA3/miR-125a-5p/IL-6R and STAT3/FOXP3 regulatory pathway, which determines how Treg cells respond to inflammatory IL-6-rich conditions.
- Subjects
TRANSCRIPTION factors; T cells; CYTOLOGICAL research; INTERLEUKIN-6; INTERLEUKINS
- Publication
Scientific Reports, 2015, p14615
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/srep14615