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- Title
The Truth Is Out There: Biological Features and Clinical Indications of Extracellular Vesicles from Human Perinatal Stem Cells.
- Authors
Russo, Eleonora; Alberti, Giusi; Corrao, Simona; Borlongan, Cesar V.; Miceli, Vitale; Conaldi, Pier Giulio; Di Gaudio, Francesca; La Rocca, Giampiero
- Abstract
The potential of perinatal tissues to provide cellular populations to be used in different applications of regenerative medicine is well established. Recently, the efforts of researchers are being addressed regarding the evaluation of cell products (secreted molecules or extracellular vesicles, EVs) to be used as an alternative to cellular infusion. The data regarding the effective recapitulation of most perinatal cells' properties by their secreted complement point in this direction. EVs secreted from perinatal cells exhibit key therapeutic effects such as tissue repair and regeneration, the suppression of inflammatory responses, immune system modulation, and a variety of other functions. Although the properties of EVs from perinatal derivatives and their significant potential for therapeutic success are amply recognized, several challenges still remain that need to be addressed. In the present review, we provide an up-to-date analysis of the most recent results in the field, which can be addressed in future research in order to overcome the challenges that are still present in the characterization and utilization of the secreted complement of perinatal cells and, in particular, mesenchymal stromal cells.
- Subjects
EXTRACELLULAR vesicles; HUMAN stem cells; CLINICAL indications; PERINATAL death; STROMAL cells; REGENERATIVE medicine
- Publication
Cells (2073-4409), 2023, Vol 12, Issue 19, p2347
- ISSN
2073-4409
- Publication type
Article
- DOI
10.3390/cells12192347