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- Title
Recellularization of Native Tissue Derived Acellular Scaffolds with Mesenchymal Stem Cells.
- Authors
Ahmed, Ebtehal; Saleh, Tarek; Xu, Meifeng
- Abstract
The functionalization of decellularized scaffolds is still challenging because of the recellularization-related limitations, including the finding of the most optimal kind of cell(s) and the best way to control their distribution within the scaffolds to generate native mimicking tissues. That is why researchers have been encouraged to study stem cells, in particular, mesenchymal stem cells (MSCs), as alternative cells to repopulate and functionalize the scaffolds properly. MSCs could be obtained from various sources and have therapeutic effects on a wide range of inflammatory/degenerative diseases. Therefore, in this mini-review, we will discuss the benefits using of MSCs for recellularization, the factors affecting their efficiency, and the drawbacks that may need to be overcome to generate bioengineered transplantable organs.
- Subjects
MESENCHYMAL stem cells; STEM cells; EXTRACELLULAR matrix; DEGENERATION (Pathology)
- Publication
Cells (2073-4409), 2021, Vol 10, Issue 7, p1787
- ISSN
2073-4409
- Publication type
Article
- DOI
10.3390/cells10071787