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- Title
Circulating Cell-Free mtDNA Contributes to AIM2 Inflammasome-Mediated Chronic Inflammation in Patients with Type 2 Diabetes.
- Authors
Bae, Jung Hwan; Jo II, Seung; Kim, Seong Jin; Lee, Jong Min; Jeong, Ji Hun; Kang, Jeong Suk; Cho, Nam-Jun; Kim, Sang Soo; Lee, Eun Young; Moon, Jong-Seok
- Abstract
Mitochondrial dysfunction has been implicated in the pathogenesis of insulin resistance and type 2 diabetes. Damaged mitochondria DNA (mtDNA) may have a role in regulating hyperglycemia during type 2 diabetes. Circulating cell-free mitochondria DNA (ccf-mtDNA) was found in serum and plasma from patients and has been linked to the prognosis factors in various human diseases. However, the role of ccf-mtDNA in chronic inflammation in type 2 diabetes is unclear. In this study, we hypothesized that the ccf-mtDNA levels are associated with chronic inflammation in patients with type 2 diabetes. The mtDNA levels were elevated in the plasma from patients with type 2 diabetes compared to healthy subjects. The elevated mtDNA levels were associated with interleukin-1β (IL-1β) levels in patients with type 2 diabetes. The mtDNA, from patients with type 2 diabetes, induced absent in melanoma 2 (AIM2) inflammasome-dependent caspase-1 activation and IL-1β and IL-18 secretion in macrophages. Our results suggest that the ccf-mtDNA might contribute to AIM2 inflammasome-mediated chronic inflammation in type 2 diabetes.
- Subjects
MITOCHONDRIAL DNA; TYPE 2 diabetes; INSULIN resistance; INFLAMMATION
- Publication
Cells (2073-4409), 2019, Vol 8, Issue 4, p328
- ISSN
2073-4409
- Publication type
Article
- DOI
10.3390/cells8040328