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- Title
Total and Toxocara canis larval excretory/secretory antigen- and allergen-specific IgE in atopic and nonatopic dogs.
- Authors
Zwickl, Lena L. M. N.; Joekel, Deborah E.; Fischer, Nina M.; Rostaher, Ana; Thamsborg, Kristian; Deplazes, Peter; Favrot, Claude
- Abstract
Background - Total IgE concentrations are higher in dogs than in humans. Persistent Toxocara canis larval infection is prevalent in dogs and is associated with substantial specific antibody reactions. A correlation, however, between total IgE and T. canis-specific antibody levels in dogs has not been evaluated. Objectives - To determine the relationship between total IgE, T. can/s-specific IgG and IgE, and allergen-specific IgE levels in atopic and non-atopic dogs, and to evaluate possible confounding factors. Animals - Sera of 30 atopic and 30 non-atopic client-owned dogs. Methods - Total IgE, T. can/s-specific antibody and allergen-specific IgE levels were evaluated by ELISA. Results - Total IgE, T. can/s-specific antibody and allergen-specific IgE levels were significantly higher in nonatopic compared to atopic dogs. A positive correlation was demonstrated between T. canis-specific IgG and T. canis-specific IgE; T. can/s-specific IgG and total IgE; T. can/s-specific IgE and total IgE; and allergen-specific IgE and total IgE. No differences were detected on the basis of age, gender, vaccination status; deworming or season between atopic and non-atopic dogs. Previous immunomodulatory treatment and cause of atopy did not influence antibody levels of atopic dogs. Conclusions - Toxocara can/s-specific IgE appears to be a major component of total IgE in dogs. Total and T. canis-specific IgE levels are higher in non-atopic compared to atopic dogs. It is speculated that T. can/s infection may have a protective effect against the development of canine atopic dermatitis and/or that elevations in total serum IgE level are often not associated with atopic dermatitis.
- Subjects
TOXOCARA; EXCRETORY organs; ANTIGENS; DOG diseases; ALLERGENS; IMMUNOGLOBULIN E; DISEASES
- Publication
Veterinary Dermatology, 2018, Vol 29, Issue 3, p222
- ISSN
0959-4493
- Publication type
Article
- DOI
10.1111/vde.12527