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- Title
A New DNA Break Repair Pathway Involving PARP3 and Base Excision Repair Proteins.
- Authors
Belousova, E. A.; Kutuzov, M. M.; Ivankina, P. A.; Ishchenko, A. A.; Lavrik, O. I.
- Abstract
Poly(ADP-ribosyl)ation, which is catalyzed by PARP family proteins, is one of the main reactions in the cell response to genomic DNA damage. Massive impact of DNA-damaging agents (such as oxidative stress and ionizing radiation) causes numerous breaks in DNA. In this case, the development of a fast cell response, which allows the genomic DNA integrity to be retained, may be more important than the repair by more accurate but long-term restoration of the DNA structure. This is the first study to show the possibility of eliminating DNA breaks through their PARP3-dependent mono(ADP-ribosyl)ation followed by ligation and repair of the formed ribo-AP sites by the base excision repair (BER) enzyme complex. Taken together, the results of the studies on ADP-ribosylation of DNA and the data obtained in this study suggest that PARP3 may be a component of the DNA break repair system involving the BER enzyme complex.
- Subjects
DNA repair; ADP-ribosylation; DNA damage; PROTEINS; OXIDATIVE stress
- Publication
Doklady Biochemistry & Biophysics, 2018, Vol 482, Issue 1, p233
- ISSN
1607-6729
- Publication type
Article
- DOI
10.1134/S1607672918050010