We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Peri‐prostatic adipose tissue: the metabolic microenvironment of prostate cancer.
- Authors
Nassar, Zeyad D.; Aref, Adel T.; Miladinovic, Dushan; Mah, Chui Yan; Raj, Ganesh V.; Hoy, Andrew J.; Butler, Lisa M.
- Abstract
Emerging data have linked certain features of clinical prostate cancer (PCa) to obesity and, more specifically, increased adiposity. Whereas the large number of clinical studies and meta‐analyses that have explored the associations between PCa and obesity have shown considerable variability, particularly in relation to prostate cancer risk, there is an accumulating weight of evidence consistently linking obesity to greater aggressiveness of disease. In probing this association mechanistically, it has been posited that peri‐prostatic adipose tissue (PPAT), a significant component of the prostate microenvironment, may be a critical source of fatty acids and other mitogens and thereby influences PCa pathogenesis and progression. Notably, several recent studies have identified secreted factors from both PPAT and PCa that potentially mediate the two‐way communication between these intimately linked tissues. In the present review, we summarize the available literature regarding the relationship between PPAT and PCa, including the potential biological mediators of that relationship, and explore emerging areas of interest for future research endeavours.
- Subjects
PROSTATE cancer; ADIPOSE tissues; OBESITY; CARCINOGENESIS; DISEASE progression
- Publication
BJU International, 2018, Vol 121, p9
- ISSN
1464-4096
- Publication type
Article
- DOI
10.1111/bju.14173