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- Title
Identification of Key Biomarkers in Systemic Lupus Erythematosus by a Multi-Cohort Analysis.
- Authors
Meilin Wei; Qiguan Dong; Shaoqiu Chen; Junlong Wang; Hua Yang; Qin Xiong
- Abstract
Systemic lupus erythematosus (SLE) is an autoimmune disease that affects multiple body systems with heterogeneous clinical manifestations. Since gene expression analyses have been accomplished on diverse types of samples to specify SLE-related genes, singlecohort transcriptomics have not produced reliable results. Using an integrated multicohort analysis framework, we analyzed whole blood cells from SLE patients from three transcriptomics cohorts (n=1222) and identified a five-gene signature that distinguished SLE patients from controls. We validated the diagnostic performance of this five-gene signature in six independent validation cohorts (n= 469), with an area under the receiver operating characteristic curve of 0.88 [95% CI 0.7 - 0.96]. This five-gene signature may be associated with the proportion of SLE immune cells, and generalizable across ages and sample types with real diagnostic value for clinical application.
- Subjects
SYSTEMIC lupus erythematosus; RECEIVER operating characteristic curves; BIOMARKERS; AUTOIMMUNE diseases; SYMPTOMS
- Publication
Frontiers in Immunology, 2022, Vol 13, p1
- ISSN
1664-3224
- Publication type
Article
- DOI
10.3389/fimmu.2022.928623