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- Title
Beta‐cell function in treatment‐naïve patients with type 2 diabetes mellitus: Analyses of baseline data from 15 clinical trials.
- Authors
Blüher, Matthias; Malhotra, Ankur; Bader, Giovanni
- Abstract
Low levels of HOMA2-B were observed mainly in patients with poor metabolic control and longer disease duration, whereas almost 100% of -cell functionality was observed in newly diagnosed patients with HbA1c <53.0 mmol/mol (7%) (Figure 2). HOMA2-B values from treated patients with T2DM showed an almost linear and uniform trend, whereas in treatment-naïve patients, a minor trough just after diagnosis was seen, indicating a higher HOMA2-B value and the trend was similar to treated patients after 3 years (Figure S3). The Lowess smoothing curve showed better HOMA2-B values in treatment-naïve versus treated patients with T2DM, especially in those with a disease duration <3 years. Keywords: disease duration; HbA1c; HOMA2-B; treatment-naïve; type 2 diabetes mellitus; -cell function EN disease duration HbA1c HOMA2-B treatment-naïve type 2 diabetes mellitus -cell function 1403 1407 5 04/04/23 20230501 NES 230501 INTRODUCTION Progressive decline of -cell function is a hallmark of disease progression in type 2 diabetes mellitus (T2DM).
- Subjects
TYPE 2 diabetes; PANCREATIC beta cells; INSULIN receptors; CLINICAL trials
- Publication
Diabetes, Obesity & Metabolism, 2023, Vol 25, Issue 5, p1403
- ISSN
1462-8902
- Publication type
Article
- DOI
10.1111/dom.14969