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- Title
Prolonged QT interval is linked to all-cause and cardiac mortality in chronic peritoneal dialysis patients.
- Authors
Kuo, Huey‐Liang; Liu, Yao‐Lung; Liang, Chih‐Chia; Chang, Chiz‐Tzung; Wang, Su‐Ming; Liu, Jiung‐Hsiun; Lin, Hsin‐Hung; Wang, I‐Kuan; Yang, Ya‐Fei; Chou, Che‐Yi; Huang, Chiu‐Ching
- Abstract
Aim Prolonged QT interval is related to changes of electrolytes in haemodialysis (HD) and is associated with all-cause mortality in HD patients. It is unknown if prolonged QT interval is associated with all-cause mortality in peritoneal dialysis (PD) patients as the electrolytes were relatively stable in PD. We therefore investigated the association of prolonged QT interval and all-cause mortality in chronic PD patients. Methods The QT intervals were measured in 2003 and all patients were followed to December 2012. A prolonged QT interval was defined as a QT interval > 450 ms. The association of prolonged QT interval with all-cause and cardiac-specific mortality was analyzed using Cox regression and Kaplan-Meier analysis. Results Of 306 patients, 196 (64%) patients had prolonged QT interval. The incidence density rate was 9.7 per 100 persons-years for all-cause mortality and 5.6 for cardiac specific mortality in patients with prolonged QT interval. Prolonged QT interval was associated with all-cause mortality with a hazard ratio (HR) of 1.59 (95% confidence interval (CI): 1.06-2.39, P = 0.03] and cardiac mortality (HR: 1.66, 95% CI: 1.00-2.78, P = 0.05) with adjustments for age, gender, diabetes, and vintage of dialysis. Longer QT interval (>500 ms, 450-500 ms, and < 450 ms) was significantly associated with a worse overall survival ( P = 0.03, log-rank test) and cardiac mortality free survival ( P = 0.05, log-rank test). Conclusions Prolonged QT interval was associated with all-cause and cardiac mortality in patients on peritoneal dialysis. The association is independent of patient's age and diabetes.
- Subjects
ELECTROLYTES; HEMODIALYSIS; MORTALITY; PERITONEAL dialysis; DIABETES
- Publication
Nephrology, 2017, Vol 22, Issue 6, p436
- ISSN
1320-5358
- Publication type
Article
- DOI
10.1111/nep.12808