We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Eco-friendly biosynthesis, anticancer drug loading and cytotoxic effect of capped Ag-nanoparticles against breast cancer.
- Authors
Nasiri, N.; Naz, M.; Qureshi, M.; Ikram, M.; Nafees, M.; Ali, S.; Tricoli, A.
- Abstract
The work aimed to prepare silver nanoparticles (Ag-NPs) from silver nitrate and various concentrations of the seed extract ( Setaria verticillata) by a green synthetic route. The chemical and physical properties of the resulting Ag-NPs were investigated by X-ray diffraction (XRD), transmission electron microscopy (TEM), Fourier transform infrared (FTIR) spectrometry and ultraviolet-visible (UV-Vis) spectrophotometry. Anticancer activity of Ag-NPs (5-20 nm) had dose-dependent cytotoxic effect against breast cancer (MCF7-FLV) cells. The in vitro toxicity was studied on adult earthworms (Lumbricina) resulting in statistically significant ( P < 0.05) inhibition. The prepared NPs were loaded with hydrophilic anticancer drugs (ACD), doxorubicin (DOX) and daunorubicin (DNR), for developing a novel drug delivery carrier having significant adsorption capacity and efficiency to remove the side effects of the medicines effective for leukemia chemotherapy.
- Subjects
SILVER nanoparticles; SETARIA; CELL-mediated cytotoxicity; ANTHELMINTICS; ANTINEOPLASTIC agents; LEUKEMIA; CANCER chemotherapy
- Publication
Applied Nanoscience, 2017, Vol 7, Issue 8, p793
- ISSN
2190-5509
- Publication type
Article
- DOI
10.1007/s13204-017-0615-6