We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Deficiencies in fat-soluble vitamins in long-term users of somatostatin analogue H.-B. Fiebrich et al. Fat-soluble vitamins and somatostatin analogues.
- Authors
Fiebrich, H.‐B.; Van Den Berg, G.; Kema, I. P.; Links, T. P.; Kleibeuker, J. H.; Van Beek, A. P.; Walenkamp, A. M. E.; Sluiter, W. J.; De Vries, E. G. E.
- Abstract
Background Somatostatin analogues are administered to control hormone hypersecretion in acromegaly and carcinoid patients. Somatostatin analogues can increase fat in the stools, which can lead to loss of fat-soluble vitamins. The effect of long-term somatostatin analogue use on vitamin levels remains unknown. Aim To investigate the prevalence of fat-soluble vitamin deficiencies in longterm somatostatin analogue users. Methods All acromegaly and carcinoid patients using somatostatin analogues for ≥ 18 months visiting the University Medical Center Groningen between December 2008 and April 2009 were eligible. Vitamin levels of fat-soluble vitamins in blood, clinical and vitamin-dependent laboratory parameters were collected. Results In all, 19 acromegaly and 35 carcinoid patients were included. Twelve patients experienced steatorrhoea; two carcinoid patients experienced night blindness. Forty-two (78%) were deficient for one or more vitamins, and 32% (n = 17) had multiple deficiencies. Deficiencies for vitamin A, D, E, K1 and E in erythrocytes occurred in 6%, 28%, 15%, 63% and 58% of the patients. Prevalence of vitamin D, E and K1 deficiencies was similar in both patient groups. Treatment duration did not influence vitamin levels. The length of intestinal resection and age correlated negatively with vitamin A levels. Conclusions Fat-soluble vitamin deficiencies are frequent during long-term somatostatin analogue treatment. Therefore, fat-soluble vitamins should be monitored in these patients.
- Subjects
ACROMEGALY; SOMATOSTATIN; CARCINOID heart disease; FECES; VITAMINS; UNIVERSITIES &; colleges; PATIENTS
- Publication
Alimentary Pharmacology & Therapeutics, 2010, Vol 32, Issue 11/12, p1398
- ISSN
0269-2813
- Publication type
Article
- DOI
10.1111/j.1365-2036.2010.04479.x