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- Title
Comparison of risk factors and clinical responses to proton pump inhibitors in patients with erosive oesophagitis and non-erosive reflux disease.
- Authors
LEE, E. S.; KIM, N.; LEE, S. H.; PARK, Y. S.; KIM, J. W.; JEONG, S. H.; LEE, D. H.; JUNG, H. C.; SONG, I. S.
- Abstract
Background There has been no report on the response to proton pump inhibitor (PPI) therapy and on-demand or the relapse rate of non-erosive reflux disease (NERD) and erosive oesophagitis in Korea. Aim To compare the risk factors, clinical symptoms and PPI responses between patients with erosive oesophagitis and NERD patients. Methods A survey was performed prospectively in the erosive oesophagitis (205 patients) and NERD group (200 patients). Clinical symptoms, risk factors and PPI responses were analysed. On-demand therapy and the relapse rate of GERD symptoms were investigated during a one-year follow-up. Results BMI ≥ 25 (OR 3.0, 95% CI 1.1–8.3), alcohol use (OR 2.9, 95% CI 1.0–8.3), hiatal hernia (OR 5.0, 95% CI 1.2–20) and triglyceride ≥150 mg/dL (OR 4.0, 95% CI 1.7–10) were more common in the erosive oesophagitis group than in the NERD group by multivariate analysis. The ratio of oesophageal to extra-oesophageal symptoms was higher in the erosive oesophagitis group compared with the NERD group ( P < 0.001). The PPI response rates at 8 weeks were different ( P = 0.02); refractory rates were higher in the NERD group (16.7%) compared with the erosive oesophagitis group (6.0%). However, there was no significant difference between the two groups in on-demand therapy or the relapse rate. Conclusion These results suggest that the underlying pathogenic mechanisms of erosive oesophagitis and NERD are distinct.
- Subjects
DISEASE risk factors; PROTON pump inhibitors; ENZYME inhibitors; ESOPHAGUS diseases; GASTROESOPHAGEAL reflux; PATIENTS
- Publication
Alimentary Pharmacology & Therapeutics, 2009, Vol 30, Issue 2, p154
- ISSN
0269-2813
- Publication type
Article
- DOI
10.1111/j.1365-2036.2009.04021.x