We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The Coagulation and Protein C Pathways in Patients with Sleep Apnea.
- Authors
Takagi, Takehiro; Morser, John; Gabazza, Esteban C.; Qin, Liqiang; Fujiwara, Atsushi; Naito, Masaki; Yamaguchi, Aiko; Kobayashi, Tetsu; D'Alessandro-Gabazza, Corina N.; Boveda Ruiz, Daniel; Bernabe, Paloma Gil; Iwasaki, Yasuhiko; Takei, Yoshiyuki; Taguchi, Osamu
- Abstract
Patients with obstructive sleep apnea (OSA) have a high frequency of cardiovascular diseases and hypercoagulability is believed to be involved in the mechanism of those vascular events. We evaluated whether there is a dysfunction in the protein C anticoagulant pathway in patients with obstructive sleep apnea. Two hundred ninety-three patients were enrolled. To confirm the diagnosis of OSA, all-night polysomnography, including determination of SpO2, was carried out. The apnea-hypopnea index (AHI) was used for judging the presence of sleep-breathing disorder. The plasma levels of the thrombin-antithrombin complex were higher in patients with AHI > 5 than in those without OSA, defined as AHI < 5. However, there was no statistically significant difference in the plasma level of either activated protein C/α-antitrypsin complex or soluble thrombomodulin between patients with AHI > 5 and those with AHI < 5. The results of this study showed for the first time that markers of the protein C anticoagulant pathway are not affected in patients with OSA and that the protein C pathway is probably not involved in the mechanism of hypercoagulability in subjects with sleep-disordered breathing.
- Subjects
SLEEP apnea syndromes; GLYCOPROTEINS; SLEEP disorder diagnosis; BLOOD coagulation factors; PROTEIN C
- Publication
Lung, 2009, Vol 187, Issue 4, p209
- ISSN
0341-2040
- Publication type
Article
- DOI
10.1007/s00408-009-9152-8