We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Algorithm for the Measure of Vitreous Hyperreflective Foci in Optical Coherence Tomographic Scans of Patients With Diabetic Macular Edema.
- Authors
Korot, Edward; Comer, Grant; Steffens, Timothy; Antonetti, David A.
- Abstract
<bold>Importance: </bold>Developing a noninvasive measure of diabetic retinopathy disease progression may provide physicians with information needed for patient-specific intervention.<bold>Objective: </bold>To develop an algorithm to measure vitreous hyperreflective foci (VHRF) from standard, 3-dimensional optical coherence tomographic (OCT) images in an unbiased manner.<bold>Design, Setting, and Participants: </bold>We retrospectively analyzed OCT scans from 97 patients who were evaluated at the Kellogg Eye Center, University of Michigan. Patients with diabetes mellitus without signs of retinopathy (n = 9) and patients with diabetic macular edema (DME) (n = 31) were compared with healthy control participants (n = 37). The algorithm was used to determine whether the VHRF score is associated with DME and may serve as a noninvasive measure of inflammation. The study was conducted from November 14, 2011, to August 5, 2015. Data analysis was performed from May 15, 2014, to August 13, 2015.<bold>Main Outcomes and Measures: </bold>An algorithm was developed to enhance the vitreous imaging from OCT to allow automated quantification of VHRF and calculation of a VHRF score. This score was compared between the healthy control, diabetes without retinopathy, and DME groups.<bold>Results: </bold>In the 97 scans evaluated, VHRF scores, reported as mean (SD), were increased in patients with DME by 2.95-fold (5.60 [8.65]) compared with healthy controls (1.90 [3.42]; 95% CI, 0.75-7.45; P = .012) and by 6.83-fold compared with patients with diabetes without retinopathy (0.82 [1.26]; 95% CI, 1.46-8.82; P = .005).<bold>Conclusions and Relevance: </bold>Scores obtained using the VHRF algorithm may be obtained from OCT images that include the vitreous and could provide a rapid, noninvasive clinical correlate for ocular inflammation. Higher VHRF scores in patients with DME compared with controls and diabetic patients without retinopathy warrant further population-based and longitudinal studies to help determine the value of the VHRF score in selecting therapeutic intervention.
- Subjects
DIABETIC retinopathy; RETINAL degeneration; ALGORITHMS; COMPARATIVE studies; GLYCOSYLATED hemoglobin; RESEARCH methodology; MEDICAL cooperation; RESEARCH; RESEARCH evaluation; RESEARCH funding; VITREOUS body; THREE-dimensional imaging; EVALUATION research; OPTICAL coherence tomography; RETROSPECTIVE studies; DIAGNOSIS
- Publication
JAMA Ophthalmology, 2016, Vol 134, Issue 1, p15
- ISSN
2168-6165
- Publication type
journal article
- DOI
10.1001/jamaophthalmol.2015.3949