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- Title
N-acetyl aspartate concentration is correlated with severity of generalized anxiety disorder.
- Authors
El-Hadidy, Mohamed Adel; Kamr, Wael Hamza
- Abstract
This study used proton magnetic resonance spectroscopy to assess concentrations of N-acetyl aspartate in patients with generalized anxiety disorder (GAD).Brain metabolite resonance was measured in the left and right dorsolateral prefrontal cortex in 20 drug-naive patients with GAD and 20 age-matched and sex-matched healthy volunteers. Correlation studies were conducted between brain metabolites and scores in the Hamilton Anxiety Rating Scale and in the Taylor's Manifest Anxiety Scale.The only statistically significant difference between the patients with GAD and their matched comparison individuals was in right N-acetyl aspartate and in right N-acetyl aspartate/creatine. There were direct correlations between either right N-acetyl aspartate or N-acetyl aspartate/creatine and the scores in the Hamilton Anxiety Scale and Taylor's Manifest Anxiety Scale in patients with GAD, but not in the control group.GAD is associated with asymmetric increases in the N-acetyl aspartate and N-acetyl aspartate/creatine ratio, which are directly correlated with the severity of GAD by psychometric scales.
- Publication
Middle East Current Psychiatry, 2011, Vol 18, Issue 3, p170
- ISSN
2090-5408
- Publication type
Article
- DOI
10.1097/01.XME.0000398570.14636.2a