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Enhanced Apoptosis and Loss of Cell Viability in Melanoma Cells by Combined Inhibition of ERK and Mcl-1 Is Related to Loss of Mitochondrial Membrane Potential, Caspase Activation and Upregulation of Proapoptotic Bcl-2 Proteins.
Published in:
International Journal of Molecular Sciences, 2023, v. 24, n. 5, p. 4961, doi. 10.3390/ijms24054961
By:
- Peng, Zhe;
- Gillissen, Bernhard;
- Richter, Antje;
- Sinnberg, Tobias;
- Schlaak, Max S.;
- Eberle, Jürgen
Publication type:
Article
The BCL-2 inhibitor ABT-199/venetoclax synergizes with proteasome inhibition via transactivation of the MCL-1 antagonist NOXA.
Published in:
Cell Death Discovery, 2022, v. 8, n. 1, p. 1, doi. 10.1038/s41420-022-01009-1
By:
- Weller, Sandra;
- Toennießen, Astrid;
- Schaefer, Benjamin;
- Beigl, Tobias;
- Muenchow, Alina;
- Böpple, Kathrin;
- Hofmann, Ute;
- Gillissen, Bernhard F.;
- Aulitzky, Walter E.;
- Kopp, Hans-Georg;
- Essmann, Frank
Publication type:
Article
Mutual Regulation of Bcl-2 Proteins Independent of the BH3 Domain as Shown by the BH3-Lacking Protein Bcl-xAK.
Published in:
PLoS ONE, 2012, v. 7, n. 4, p. 1, doi. 10.1371/journal.pone.0034549
By:
- Plötz, Michael;
- Hossini, Amir M.;
- Gillissen, Bernhard;
- Daniel, Peter T.;
- Stockfleth, Eggert;
- Eberle, Jürgen
Publication type:
Article
BCL-2 and BOK regulate apoptosis by interaction of their C-terminal transmembrane domains.
Published in:
EMBO Reports, 2024, v. 25, n. 9, p. 3896, doi. 10.1038/s44319-024-00206-6
By:
- Beigl, Tobias B;
- Paul, Alexander;
- Fellmeth, Thomas P;
- Nguyen, Dang;
- Barber, Lynn;
- Weller, Sandra;
- Schäfer, Benjamin;
- Gillissen, Bernhard F;
- Aulitzky, Walter E;
- Kopp, Hans-Georg;
- Rehm, Markus;
- Andrews, David W;
- Pluhackova, Kristyna;
- Essmann, Frank
Publication type:
Article
Caspase-independent induction of apoptosis in human melanoma cells by the proapoptotic Bcl-2-related protein Nbk / Bik.
Published in:
Oncogene, 2005, v. 24, n. 49, p. 7369, doi. 10.1038/sj.onc.1208890
By:
- Oppermann, Malte;
- Geilen, Christoph C.;
- Fecker, Lothar F.;
- Gillissen, Bernhard;
- Daniel, Peter T.;
- Eberle, Jürgen
Publication type:
Article
Multidomain Bcl-2 homolog Bax but not Bak mediates synergistic induction of apoptosis by TRAIL and 5-FU through the mitochondrial apoptosis pathway.
Published in:
Oncogene, 2004, v. 23, n. 50, p. 8320, doi. 10.1038/sj.onc.1207971
By:
- von Haefen, Clarissa;
- Gillissen, Bernhard;
- Hemmati, Philipp G.;
- Wendt, Jana;
- Güner, Dilek;
- Mrozek, Alicja;
- Belka, Claus;
- Dörken, Bernd;
- Daniel, Peter T.
Publication type:
Article
Smac induces cytochrome c release and apoptosis independently from Bax/Bcl-xL in a strictly caspase-3-dependent manner in human carcinoma cells.
Published in:
Oncogene, 2004, v. 23, n. 26, p. 4523, doi. 10.1038/sj.onc.1207594
By:
- Hasenjäger, Anne;
- Gillissen, Bernhard;
- Müller, Antje;
- Normand, Guillaume;
- Hemmati, Philipp G.;
- Schuler, Martin;
- Dörken, Bernd;
- Daniel, Peter T.
Publication type:
Article
Adenovirus-mediated overexpression of p14[supARF] induces p53 and Bax-independent apoptosis.
Published in:
Oncogene, 2002, v. 21, n. 20, p. 3149, doi. 10.1038/sj.onc.1205458
By:
- Hemmati, Phillip G.;
- Gillissen, Bernhard;
- von Haefen, Clarissa;
- Wendt, Jana;
- Starck, Lilian;
- Guner, Dilek;
- Dorken, Bernd;
- Daniel, Peter T.
Publication type:
Article
The apoptosis promoting Bcl-2 homologues Bak and Nbk/Bik overcome drug resistance in Mdr-1-negative and mdr-1-overexpressing breat cancer cell lines.
Published in:
Oncogene, 2002, v. 21, n. 2, p. 227, doi. 10.1038/sj.onc.1205010
By:
- Radetzki, Silke;
- Kohne, Claus-Henning;
- von Haefen, Clarissa;
- Gillissen, Bernhard;
- Sturm, Isrid;
- Dorken, Bernd;
- Daniel, Peter T.
Publication type:
Article
MTCH2/MIMP is a major facilitator of tBID recruitment to mitochondria.
Published in:
Nature Cell Biology, 2010, v. 12, n. 6, p. 553, doi. 10.1038/ncb2057
By:
- Zaltsman, Yehudit;
- Shachnai, Liat;
- Yivgi-Ohana, Natalie;
- Schwarz, Michal;
- Maryanovich, Maria;
- Houtkooper, Riekelt H.;
- Vaz, Frédéric Maxime;
- De Leonardis, Francesco;
- Fiermonte, Giuseppe;
- Palmieri, Ferdinando;
- Gillissen, Bernhard;
- Daniel, Peter T.;
- Jimenez, Erin;
- Walsh, Susan;
- Koehler, Carla M.;
- Roy, Soumya Sinha;
- Walter, Ludivine;
- Hajnóczky, György;
- Gross, Atan
Publication type:
Article
Alectinib treatment improves photodynamic therapy in cancer cell lines of different origin.
Published in:
2021
By:
- Gillissen, Bernhard;
- Richter, Antje;
- Essmann, Frank;
- Kemmner, Wolfgang
Publication type:
journal article
Endogenous Bak inhibitors Mcl-1 and Bcl-xL: differential impact on TRAIL resistance in Bax-deficient carcinoma.
Published in:
Journal of Cell Biology, 2010, v. 188, n. 6, p. 851, doi. 10.1083/jcb.200912070
By:
- Gillissen, Bernhard;
- Wendt, Jana;
- Richter, Antje;
- Richter, Anja;
- Müer, Annika;
- Overkamp, Tim;
- Gebhardt, Nina;
- Preissner, Robert;
- Belka, Claus;
- Dörken, Bernd;
- Daniel, Peter T.
Publication type:
Article
Mcl-1 determines the Bax dependency of Nbk/Bik-induced apoptosis.
Published in:
Journal of Cell Biology, 2007, v. 179, n. 4, p. 701, doi. 10.1083/jcb.200703040
By:
- Gillissen, Bernhard;
- Essmann, Frank;
- Hemmati, Philipp G.;
- Richter, Antje;
- Richter, Anja;
- Öztop, Ilker;
- Chinnadurai, Govindaswamy;
- Dörken, Bernd;
- Daniel, Peter T.
Publication type:
Article
Apoptosis resistance, mitotic catastrophe, and loss of ploidy control in Burkitt lymphoma.
Published in:
Journal of Molecular Medicine, 2015, v. 93, n. 5, p. 559, doi. 10.1007/s00109-014-1242-2
By:
- Chumduri, Cindrilla;
- Gillissen, Bernhard;
- Richter, Anja;
- Richter, Antje;
- Milojkovic, Ana;
- Overkamp, Tim;
- Müller, Anja;
- Pott, Christiane;
- Daniel, Peter
Publication type:
Article
Contribution of BH3-domain and Transmembrane-domain to the Activity and Interaction of the Pore-forming Bcl-2 Proteins Bok, Bak, and Bax.
Published in:
Scientific Reports, 2018, v. 8, n. 1, p. 1, doi. 10.1038/s41598-018-30603-6
By:
- Stehle, Daniel;
- Grimm, Melanie;
- Einsele-Scholz, Stephanie;
- Ladwig, Friederike;
- Johänning, Janina;
- Fischer, Gerd;
- Gillissen, Bernhard;
- Schulze-Osthoff, Klaus;
- Essmann, Frank
Publication type:
Article
Identification of signature volatiles to discriminate Candida albicans, glabrata, krusei and tropicalis using gas chromatography and mass spectrometry.
Published in:
Mycoses, 2016, v. 59, n. 2, p. 117, doi. 10.1111/myc.12442
By:
- Hertel, Moritz;
- Hartwig, Stefan;
- Schütte, Eyke;
- Gillissen, Bernhard;
- Preissner, Robert;
- Schmidt‐Westhausen, Andrea Maria;
- Paris, Sebastian;
- Kastner, Isabell;
- Preissner, Saskia
Publication type:
Article
Effective Targeting of Melanoma Cells by Combination of Mcl-1 and Bcl-2/Bcl-x L /Bcl-w Inhibitors.
Published in:
International Journal of Molecular Sciences, 2024, v. 25, n. 6, p. 3453, doi. 10.3390/ijms25063453
By:
- Peng, Zhe;
- Gillissen, Bernhard;
- Richter, Antje;
- Sinnberg, Tobias;
- Schlaak, Max S.;
- Eberle, Jürgen
Publication type:
Article

Found: 17

Enhanced Apoptosis and Loss of Cell Viability in Melanoma Cells by Combined Inhibition of ERK and Mcl-1 Is Related to Loss of Mitochondrial Membrane Potential, Caspase Activation and Upregulation of Proapoptotic Bcl-2 Proteins.

The BCL-2 inhibitor ABT-199/venetoclax synergizes with proteasome inhibition via transactivation of the MCL-1 antagonist NOXA.

Mutual Regulation of Bcl-2 Proteins Independent of the BH3 Domain as Shown by the BH3-Lacking Protein Bcl-x<sub>AK</sub>.

BCL-2 and BOK regulate apoptosis by interaction of their C-terminal transmembrane domains.

Caspase-independent induction of apoptosis in human melanoma cells by the proapoptotic Bcl-2-related protein Nbk / Bik.

Multidomain Bcl-2 homolog Bax but not Bak mediates synergistic induction of apoptosis by TRAIL and 5-FU through the mitochondrial apoptosis pathway.

Smac induces cytochrome c release and apoptosis independently from Bax/Bcl-x<sub>L</sub> in a strictly caspase-3-dependent manner in human carcinoma cells.

Adenovirus-mediated overexpression of p14[supARF] induces p53 and Bax-independent apoptosis.

The apoptosis promoting Bcl-2 homologues Bak and Nbk/Bik overcome drug resistance in Mdr-1-negative and mdr-1-overexpressing breat cancer cell lines.

MTCH2/MIMP is a major facilitator of tBID recruitment to mitochondria.

Alectinib treatment improves photodynamic therapy in cancer cell lines of different origin.

Endogenous Bak inhibitors Mcl-1 and Bcl-x<sub>L</sub>: differential impact on TRAIL resistance in Bax-deficient carcinoma.

Mcl-1 determines the Bax dependency of Nbk/Bik-induced apoptosis.

Apoptosis resistance, mitotic catastrophe, and loss of ploidy control in Burkitt lymphoma.

Contribution of BH3-domain and Transmembrane-domain to the Activity and Interaction of the Pore-forming Bcl-2 Proteins Bok, Bak, and Bax.

Identification of signature volatiles to discriminate Candida albicans, glabrata, krusei and tropicalis using gas chromatography and mass spectrometry.

Effective Targeting of Melanoma Cells by Combination of Mcl-1 and Bcl-2/Bcl-x L /Bcl-w Inhibitors.