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- Title
Store-operated calcium entry in vascular smooth muscle.
- Authors
Leung, F. P.; Yung, L. M.; Yao, X.; Laher, I.; Huang, Y.
- Abstract
In non-excitable cells, activation of G-protein-coupled phospholipase C (PLC)-linked receptors causes the release of Ca2+ from intracellular stores, which is followed by transmembrane Ca2+ entry. This Ca2+ entry underlies a small and sustained phase of the cellular [Ca2+]i increases and is important for several cellular functions including gene expression, secretion and cell proliferation. This form of transmembrane Ca2+ entry is supported by agonist-activated Ca2+-permeable ion channels that are activated by store depletion and is referred to as store-operated Ca2+ entry (SOCE) and represents a major pathway for agonist-induced Ca2+ entry. In excitable cells such as smooth muscle cells, Ca2+ entry mechanisms responsible for sustained cellular activation are normally considered to be mediated via either voltage-operated or receptor-operated Ca2+ channels. Although SOCE occurs following agonist activation of smooth muscle, this was thought to be more important in replenishing Ca2+ stores rather than acting as a source of activator Ca2+ for the contractile process. This review summarizes our current knowledge of SOCE as a regulator of vascular smooth muscle tone and discusses its possible role in the cardiovascular function and disease. We propose a possible hypothesis for its activation and suggest that SOCE may represent a novel target for pharmacological therapeutic intervention.British Journal of Pharmacology (2008) 153, 846–857; doi:10.1038/sj.bjp.0707455; published online 17 September 2007
- Subjects
G proteins; VASCULAR smooth muscle; CALCIUM in the body; CELL proliferation; PHARMACOLOGY
- Publication
British Journal of Pharmacology, 2008, Vol 153, Issue 5, p846
- ISSN
0007-1188
- Publication type
Article
- DOI
10.1038/sj.bjp.0707455