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- Title
Impaired motion perception is associated with functional and structural visual pathway damage in multiple sclerosis and neuromyelitis optica spectrum disorders.
- Authors
Ayadi, Noah; Oertel, Frederike C; Asseyer, Susanna; Rust, Rebekka; Duchow, Ankelien; Kuchling, Joseph; Bellmann-Strobl, Judith; Ruprecht, Klemens; Klistorner, Alexander; Brandt, Alexander U; Paul, Friedemann; Zimmermann, Hanna G
- Abstract
Background: Decreased motion perception has been suggested as a marker for visual pathway demyelination in optic neuritis (ON) and/or multiple sclerosis (MS). Objectives: To examine the influence of neuro-axonal damage on motion perception in MS and neuromyelitis optica spectrum disorders (NMOSD). Methods: We analysed motion perception with numbers-from-motion (NFM), visual acuity, (multifocal (mf)) VEP, optical coherence tomography in patients with MS (n = 38, confirmatory cohort n = 43), NMOSD (n = 13) and healthy controls (n = 33). Results: NFM was lower compared with controls in MS (B = −12.37, p < 0.001) and NMOSD (B = −34.5, p < 0.001). NFM was lower in ON than in non-ON eyes (B = −30.95, p = 0.041) in NMOSD, but not MS. In MS and NMOSD, lower NFM was associated with worse visual acuity (B = −139.4, p < 0.001/ B = −77.2, p < 0.001) and low contrast letter acuity (B = 0.99, p = 0.002/ B = 1.6, p < 0.001), thinner peripapillary retinal nerve fibre layer (B = 1.0, p < 0.001/ B = 0.92, p = 0.016) and ganglion cell/inner plexiform layer (B = 64.8, p < 0.001/ B = 79.5, p = 0.006), but not with VEP P100 latencies. In the confirmatory MS cohort, lower NFM was associated with thinner retinal nerve fibre layer (B = 1.351, p < 0.001) and increased mfVEP P100 latencies (B = −1.159, p < 0.001). Conclusions: Structural neuro-axonal visual pathway damage is an important driver of motion perception impairment in MS and NMOSD.
- Subjects
NEUROMYELITIS optica; VISUAL pathways; MULTIPLE sclerosis; OPTICAL coherence tomography; OPTIC neuritis
- Publication
Multiple Sclerosis Journal, 2022, Vol 28, Issue 5, p757
- ISSN
1352-4585
- Publication type
Article
- DOI
10.1177/13524585211032801