We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Limitations and Prospects for Diffusion-Weighted MRI of the Prostate.
- Authors
Bourne, Roger; Panagiotaki, Eleftheria
- Abstract
Diffusion-weighted imaging (DWI) is the most effective component of the modern multi-parametric magnetic resonance imaging (mpMRI) scan for prostate pathology. DWI provides the strongest prediction of cancer volume, and the apparent diffusion coefficient (ADC) correlates moderately with Gleason grade. Notwithstanding the demonstrated cancer assessment value of DWI, the standard measurement and signal analysis methods are based on a model of water diffusion dynamics that is well known to be invalid in human tissue. This review describes the biophysical limitations of the DWI component of the current standard mpMRI protocol and the potential for significantly improved cancer assessment performance based on more sophisticated measurement and signal modeling techniques.
- Subjects
PROSTATE; PROSTATE disease diagnosis; TISSUE analysis; CANCER diagnosis; DIFFUSION coefficients; MAGNETIC resonance imaging
- Publication
Diagnostics (2075-4418), 2016, Vol 6, Issue 2, p21
- ISSN
2075-4418
- Publication type
Article
- DOI
10.3390/diagnostics6020021