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- Title
BHV-1 induced oxidative stress contributes to mitochondrial dysfunction in MDBK cells.
- Authors
Liqian Zhu; Chen Yuan; Dong Zhang; Yan Ma; Xiuyan Ding; Guoqiang Zhu
- Abstract
The levels of cellular reactive oxygen species (ROS) and ATP as well as the mitochondrial membrane potential (MMP) in response to bovine herpesvirus 1 (BHV-1) infection of MDBK cells were measured, respectively. BHV-1 infection increased ROS production which depended on viral entry, and de novo protein expression and/or DNA replication. Vice versa, excessive ROS was required for efficient viral replication. Levels of both ATP and MMP were significantly decreased after BHV-1 infection. Interestingly, the loss of MMP was ameliorated by ROS depression. Collectively, ROS dependent mitochondrial damage and ultimately disruption of energy metabolism (ATP depletion) are a potential pathogenic mechanism for BHV-1 infection.
- Subjects
BOVINE herpesvirus-1; MITOCHONDRIAL pathology; OXIDATIVE stress; REACTIVE oxygen species; VIRAL replication; ENERGY metabolism
- Publication
Veterinary Research, 2016, Vol 47, p1
- ISSN
0928-4249
- Publication type
Article
- DOI
10.1186/s13567-016-0332-2