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- Title
BEACON: A Summary Framework to Overcome Potential Reimbursement Hurdles.
- Authors
Dunlop, William; Mullins, C.; Pirk, Olaf; Goeree, Ron; Postma, Maarten; Enstone, Ashley; Heron, Louise; Dunlop, William C N; Mullins, C Daniel; Postma, Maarten J
- Abstract
<bold>Objective: </bold>To provide a framework for addressing payers' criteria during the development of pharmaceuticals.<bold>Methods: </bold>A conceptual framework was presented to an international health economic expert panel for discussion. A structured literature search (from 2010 to May 2015), using the following databases in Ovid: Medline(®) and Medline(®) In-Process (PubMed), Embase (Ovid), EconLit (EBSCOhost) and the National Health Service Economic Evaluation Database (NHS EED), and a 'grey literature' search, were conducted to identify existing criteria from the payer perspective. The criteria assessed by existing frameworks and guidelines were collated; the most commonly reported criteria were considered for inclusion in the framework. A mnemonic was conceived as a memory aide to summarise these criteria.<bold>Results: </bold>Overall, 41 publications were identified as potentially relevant to the objective. Following further screening, 26 were excluded upon full-text review on the basis of no framework presented (n = 13), redundancy (n = 11) or abstract only (n = 2). Frameworks that captured criteria developed for or utilised by the pharmaceutical industry (n = 5) and reimbursement guidance (n = 10) were reviewed. The most commonly identified criteria-unmet need/patient burden, safety, efficacy, quality-of-life outcomes, environment, evidence quality, budget impact and comparator-were incorporated into the summary framework. For ease of communication, the following mnemonic was developed: BEACON (Burden/target population, Environment, Affordability/value, Comparator, Outcomes, Number of studies/quality of evidence).<bold>Conclusions: </bold>The BEACON framework aims to capture the 'essence' of payer requirements by addressing the most commonly described criteria requested by payers regarding the introduction of a new pharmaceutical.
- Subjects
DRUG development; HEALTH insurance reimbursement; PHARMACEUTICAL industry; PATIENT safety; DRUG efficacy; QUALITY of life; DRUGS &; economics; INDUSTRIES &; economics; ABBREVIATIONS; MEDICAL information storage &; retrieval systems; MEDICAL protocols; MEDLINE; ONLINE information services; SYSTEMATIC reviews
- Publication
PharmacoEconomics, 2016, Vol 34, Issue 10, p1051
- ISSN
1170-7690
- Publication type
journal article
- DOI
10.1007/s40273-016-0427-7