We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Perinatal murine cytomegalovirus infection reshapes the transcriptional profile and functionality of NK cells.
- Authors
Rožmanić, Carmen; Lisnić, Berislav; Pribanić Matešić, Marina; Mihalić, Andrea; Hiršl, Lea; Park, Eugene; Lesac Brizić, Ana; Indenbirken, Daniela; Viduka, Ina; Šantić, Marina; Adler, Barbara; Yokoyama, Wayne M.; Krmpotić, Astrid; Juranić Lisnić, Vanda; Jonjić, Stipan; Brizić, Ilija
- Abstract
Infections in early life can elicit substantially different immune responses and pathogenesis than infections in adulthood. Here, we investigate the consequences of murine cytomegalovirus infection in newborn mice on NK cells. We show that infection severely compromised NK cell maturation and functionality in newborns. This effect was not due to compromised virus control. Inflammatory responses to infection dysregulated the expression of major transcription factors governing NK cell fate, such as Eomes, resulting in impaired NK cell function. Most prominently, NK cells from perinatally infected mice have a diminished ability to produce IFN-γ due to the downregulation of long non-coding RNA Ifng-as1 expression. Moreover, the bone marrow's capacity to efficiently generate new NK cells is reduced, explaining the prolonged negative effects of perinatal infection on NK cells. This study demonstrates that viral infections in early life can profoundly impact NK cell biology, including long-lasting impairment in NK cell functionality. Early life infections are known to impact and modulate the immune response in later life. Here the authors show that perinatal infection with murine cytomegalovirus results in a modified transcriptional profile and functionality in murine NK cells.
- Subjects
KILLER cells; CYTOMEGALOVIRUS diseases; GENE expression; LINCRNA; VERTICAL transmission (Communicable diseases); PERINATAL death
- Publication
Nature Communications, 2023, Vol 14, Issue 1, p1
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/s41467-023-42182-w