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- Title
Inflammasome and gasdermin signaling in neutrophils.
- Authors
Yow, See Jie; Yeap, Hui Wen; Chen, Kaiwen W.
- Abstract
Inflammasomes and gasdermins mount potent host defense pathways against invading microbial pathogens, however, dysregulation in these pathways can drive a variety of inflammatory disorders. Neutrophils, historically regarded as effector phagocytes that drive host defense via microbial killing, are now emerging as critical drivers of immunity in vivo. Here, we summarize, the latest advancement in inflammasome, gasdermin, and cell death signaling in neutrophils. We discuss the mechanisms by which neutrophils resist caspase‐1‐dependent pyroptosis, the lytic function of gasdermin D and E during NETosis and Yersinia infection, and the contribution of neutrophil inflammasomes to inflammatory disorders.
- Subjects
INFLAMMASOMES; CELL death; NEUTROPHILS; PHAGOCYTES; CELL communication; PYROPTOSIS; YERSINIA
- Publication
Molecular Microbiology, 2022, Vol 117, Issue 5, p961
- ISSN
0950-382X
- Publication type
Article
- DOI
10.1111/mmi.14891