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- Title
RESEARCH ADVANCES IN ERYTHROID DEVELOPMENT FROM HUMAN PLURIPOTENT STEM CELLS.
- Authors
Yijin Chen; Bin Mao; Jia Feng; Yonggang Zhang; Feng Ma
- Abstract
Erythroid cells play an essential role in whole life of mammals, particularly in supporting the growth and survival of the embryo/fetus. Human erythropoiesis has already been precisely described in adult but not yet in embryo. Human pluripotent stem cells (hPSCs) are of great potential for tissue substitutes (for example, blood cells) and to cure various congenital disorders. So far, many laboratories have reported that mature erythrocytes could be efficiently generated from hPSCs using different methods. Recent reports show that hPSCderived hematopoiesis follows two different pathways, and erythrocytes as the earliest developed blood cells have a unique developmental pathway through hematopoiesis. In this chapter, we summarize advances in hPSC-derived erythroid development and molecular regulatory mechanism. These researches may provide a new perspective on human embryo erythropoiesis and a possible treatment for some hematological diseases. The critical problems need to be solved and the research prospects of this field will also be addressed at the end of the chapter.
- Subjects
HUMAN stem cells; BLOOD cells; HUMAN embryos; HEMATOPOIESIS; ERYTHROPOIESIS; ERYTHROCYTES; ERYTHROCYTE membranes; PLURIPOTENT stem cells
- Publication
Journal of Stem Cells, 2020, Vol 15, Issue 1, p1
- ISSN
1556-8539
- Publication type
Article