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- Title
Improvement of Arterial Stiffness by a Natural Antioxidant Preparation.
- Authors
Öckerman, P. A.
- Abstract
Single, oligo- and multi-nutrient preparations, food extracts, nutritional and life-style interventions have been found to diminish risk factors for cardiovascular disease (CVD). Objectives: To determine if a preparation of natural antioxidants (Andox) mitigates CVD risk factors in individuals with pathological values for pulse wave velocity (PWV). Design: Case series involving 30 patients, age 45-87 years, mean age 67.6 years, involving 19 females and 11 males. Setting: Private medical practice (Bohus-Björkö, Sweden). Intervention: ANDOX tablet with a unique mixture of extracts of blueberry, grape seed, green tea, arctic raspberry, pollen and SOD (Mirorcle Pte Ltd, Singapore) was taken orally during four months. Main outcome measures: Arterial stiffness in the aorta, endothelial function of small arteries and arterial and central blood pressure was assayed monthly by the Arteriograph during four months of treatment. Values were compared to age-matched values in the Swedish population and biological age was calculated. Assays were also made of brachial blood pressure, advanced glycation end products and oxidative stress. Results: Statistically significant improvement was seen for several different CVD risk factors: Brachial systolic and diastolic blood pressure, central systolic blood pressure, aortic stiffness as measured by pulse wave velocity (PWV), endothelial function in small arteries and arterioles as measured by augmentation index (AIX), oxidative stress and advanced glycation end products. The biological age for PWV decreased by 37 years and for AIX by 31 years, which means that the risk for a CVD-event went from much higher to the same as in the reference population. Also oxidative stress was highly significantly decreased as measured by erythrocyte fragility. There was also a tendency to a decrease of advanced glycation end products. Conclusion: Certain documented risk factors such as aortic sti!ness and endothelial function of small arteries for CVD events like stroke and myocardial infarction are not normally measured in the clinical routine or known by the patient ("hidden risk factors"). It is well known that in about 50% of all first such CVD events no risk factors were known. This study indicates that ANDOX tablet with a unique mixture of natural antioxidant-rich extracts of blueberry, grape seed, green tea, arctic raspberry, pollen and SOD (Mirorcle Pte Ltd, Singapore) may diminish such risk factors significantly, thereby probably influence CVD morbidity and mortality. It is stressed that studies with antioxidants always must be performed with a broad spectrum of components, since single nutrients most often are ineffective.
- Subjects
ARTERIAL diseases; ANTIOXIDANTS; CARDIOVASCULAR diseases risk factors; PATHOLOGY; ARCTIC raspberry; BLOOD pressure
- Publication
Journal of Orthomolecular Medicine, 2015, Vol 30, Issue 2, p103
- ISSN
0834-4825
- Publication type
Article