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- Title
Clinical and Metabolomic Effects of Lactiplantibacillus plantarum and Pediococcus acidilactici in Fructose Intolerant Patients.
- Authors
Portincasa, Piero; Celano, Giuseppe; Serale, Nadia; Vitellio, Paola; Calabrese, Francesco Maria; Chira, Alexandra; David, Liliana; Dumitrascu, Dan L.; De Angelis, Maria
- Abstract
Fructose intolerance (FI) is a widespread non-genetic condition in which the incomplete absorption of fructose leads to gastro-intestinal disorders. The crucial role of microbial dysbiosis on the onset of these intolerance symptoms together with their persistence under free fructose diets are driving the scientific community towards the use of probiotics as a novel therapeutic approach. In this study, we evaluated the prevalence of FI in a cohort composed of Romanian adults with Functional Grastrointestinal Disorders (FGIDs) and the effectiveness of treatment based on the probiotic formulation EQBIOTA® (Lactiplantibacillus plantarum CECT 7484 and 7485 and Pediococcus acidilactici CECT 7483). We evaluated the impact of a 30-day treatment both on FI subjects and healthy volunteers. The gastrointestinal symptoms and fecal volatile metabolome were evaluated. A statistically significant improvement of symptoms (i.e., bloating, and abdominal pain) was reported in FI patient after treatment. On the other hand, at the baseline, the content of volatile metabolites was heterogeneously distributed between the two study arms, whereas the treatment led differences to decrease. From our analysis, how some metabolomics compounds were correlated with the improvement and worsening of clinical symptoms clearly emerged. Preliminary observations suggested how the improvement of gastrointestinal symptoms could be induced by the increase of anti-inflammatory and protective substrates. A deeper investigation in a larger patient cohort subjected to a prolonged treatment would allow a more comprehensive evaluation of the probiotic treatment effects.
- Subjects
PATHOGENESIS; IN vivo studies; MICROBIOLOGY; PHENOMENOLOGICAL biology; METABOLOMICS; GUT microbiome; GASTROINTESTINAL diseases; FRUCTOSE; LACTOSE intolerance; RESEARCH funding; BODY mass index; SHORT-chain fatty acids; LONGITUDINAL method
- Publication
Nutrients, 2022, Vol 14, Issue 12, p2488
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu14122488