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- Title
Adipocytokine Regulation and Antiangiogenic Activity Underlie the Molecular Mechanisms of Therapeutic Effects of Phyllanthus niruri against Non-Alcoholic Fatty Liver Disease.
- Authors
Al Zarzour, Raghdaa Hamdan; Alshawsh, Mohammed A.; Asif, Muhammad; Al-Mansoub, Majed Ahmed; Mohamed, Zahurin; Ahmad, Mariam; Abdul Majid, Amin Malik Shah; Asmawi, Mohd. Zaini; Kaur, Gurjeet; Al-dualimi, Dhamraa Waleed; Yam, Mun Fei
- Abstract
The growth of adipose tissues is considered angiogenesis-dependent during non-alcoholic fatty liver disease (NAFLD). We have recently reported that our standardized 50% methanolic extract (ME) of <italic>Phyllanthus niruri</italic> (50% ME of <italic>P. niruri</italic>) has alleviated NAFLD in Sprague–Dawley rats. This study aimed to assess the molecular mechanisms of action, and to further evaluate the antiangiogenic effect of this extract. NAFLD was induced by eight weeks of high-fat diet, and treatment was applied for four weeks. Antiangiogenic activity was assessed by aortic ring assay and by in vitro tests. Our findings demonstrated that the therapeutic effects of 50% ME among NAFLD rats, were associated with a significant increase in serum adiponectin, reduction in the serum levels of RBP4, vaspin, progranulin, TNF-α, IL-6, and significant downregulation of the hepatic gene expression of PPARγ, SLC10A2, and Collα1. Concomitantly, 50% ME of <italic>P. niruri</italic> has exhibited a potent antiangiogenic activity on ring assay, cell migration, vascular endothelial growth factor (VEGF), and tube formation, without any cytotoxic effect. Together, our findings revealed that the protective effects of <italic>P. niruri</italic> against NAFLD might be attributed to its antiangiogenic effect, as well as to the regulation of adipocytokines and reducing the expression of adipogenic genes.
- Subjects
ANIMAL experimentation; BIOLOGICAL assay; CELL motility; FATTY liver; FAT content of food; GENE expression; INTERLEUKINS; MEDICINAL plants; NEOVASCULARIZATION; RATS; TUMOR necrosis factors; PLANT extracts; VASCULAR endothelial growth factors; TREATMENT effectiveness; ADIPONECTIN; ADIPOKINES; IN vitro studies
- Publication
Nutrients, 2018, Vol 10, Issue 8, p1057
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu10081057