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- Title
Diagnostic accuracy of <sup>18</sup>F-FDG PET/CT in the evaluation of recurrent ovarian cancer.
- Authors
Nawi, Norazlina Mat; Mohamad, Irfan; Abdul Khader, Mohamed Ali; Shuaib, Ibrahim Lutfi
- Abstract
Objective: Ovarian cancer recurrence is often a major problem for patients who have undergone treatment. This prospective study was undertaken to evaluate the diagnostic accuracy of positron emission tomography (PET) with F-18 fluorodeoxyglucose (FDG)/ computed tomography (CT) in patients with suspected for ovarian cancer recurrence. Methods: A total of 43 women who underwent surgery or chemotherapy for ovarian cancer were enrolled in this study. They underwent18 F-FDG PET/CT scan due to raised CA-125 levels, clinical suspicion of ovarian cancer recurrence, or alterations detected on CT.18 F-FDG PET/CT findings for the women were compared with the final diagnosis. Results: CA-125 was elevated in 13 patients, while 34 patients presented with alterations on CT, and 9 patients presented with both results’ positivity. 17 patients confirmed to have an ovarian cancer recurrence, all with abnormal findings on PET/ CT. 20 patients remained disease-free during follow-up, all with normal PET/CT findings. There were 9 patients with raised CA-125 levels and normal conventional imaging, all with positive18 F-FDG PET/CT. Among the 30 patients with normal CA-125 levels, 9 patients presented with a positive PET/CT scan. Lymph nodes were the most frequent site. Its sensitivity, specificity, positive predictive value, and negative predictive valuewere 94%, 91%, 77%, and 95%, respectively. Conclusion: 18 F-FDG PET/CT is a useful modality for evaluating the cancer recurrence and extent of the disease. Lymph nodes were the most frequent site. However, there was no statistical significance found between CA-125 levels and 18F-FDG PET/CT findings.
- Subjects
CA 125 test; COMPUTED tomography; OVARIAN cancer; POSITRON emission tomography computed tomography; CANCER relapse; FLUORODEOXYGLUCOSE F18
- Publication
Bangladesh Journal of Medical Science, 2021, Vol 20, Issue 2, p302
- ISSN
2223-4721
- Publication type
Article
- DOI
10.3329/bjms.v20i2.51539