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- Title
The Effects of Allogeneic Blood Transfusion in Hepatic Resection.
- Authors
Yoshihiro Inoue; Masatsugu Ishii; Kensuke Fujii; Kazuya Kitada; Toru Kuramoto; Yoshiaki Takano; Kentaro Matsuo; Atsushi Tomioka; Toshifumi Yamaguchi; Keisuke Yokohama; Hideko Ohama; Satoshi Harada; Wataru Osumi; Yusuke Tsuchimoto; Tetsuji Terazawa; Takeshi Ogura; Shinsuke Masubuchi; Masashi Yamamoto; Akira Imoto; Akira Asai
- Abstract
<bold>Background: </bold>Hepatectomy has a high risk of perioperative bleeding due to the underlying disease. Here, we investigated the postoperative impact of allogeneic blood transfusion during hepatectomy.<bold>Methods: </bold>The surgical outcomes in 385 patients who underwent hepatic resection for hepatocellular carcinoma were retrospectively reviewed. The association of allogeneic blood transfusion with surgical outcomes and remnant liver regeneration data was analyzed.<bold>Results: </bold>Eighty-six patients (24.0%) received an allogeneic blood transfusion and 272 patients (76.0%) did not. After propensity score matching, the incidence rates of postoperative complication (Clavien-Dindo grade >IIIA), posthepatectomy liver failure, and massive ascites were significantly higher for the group that received a blood transfusion than for the group that did not receive blood transfusion (P < .001, P = .001, and <.001, respectively). Postoperative measures of total bilirubin, albumin, platelet count, prothrombin time, aspartate aminotransferase, and alanine aminotransferase were significantly more favorable in patients without blood transfusion until day 7 after surgery. There were no correlations in the remnant liver regeneration at 7 days, and 1, 2, 5, and 12 months postoperatively between the 2 groups (P = .585, .383, .507, .261, and .430, respectively). Regarding prognosis, there was no significant difference in overall and recurrence-free survival between the 2 groups (P = .065 and .166, respectively).<bold>Conclusion: </bold>Allogeneic transfusion during hepatectomy strongly affected remnant liver function in the early postoperative period; however, this was not related to the remnant liver regeneration volume. Despite that the allogeneic transfusion resulted in poorer postoperative laboratory test results and increased postoperative complication and mortality rates, it had no effect on the long-term prognosis.
- Subjects
BLOOD transfusion; LIVER regeneration; PROPENSITY score matching; LIVER surgery; PARACENTESIS; ALANINE aminotransferase; ASPARTATE aminotransferase
- Publication
American Surgeon, 2021, Vol 87, Issue 2, p228
- ISSN
0003-1348
- Publication type
journal article
- DOI
10.1177/0003134820950285