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- Title
Elevated serum chromogranin A concentrations in small-cell lung carcinoma.
- Authors
Sobol, Robert E.; O'Connor, Daniel T.; Addison, Judith; Suchocki, Karen; Royston, Ivor; Deftos, Leonard J.; Sobol, R E; O'Connor, D T; Addison, J; Suchocki, K; Royston, I; Deftos, L J
- Abstract
Serum chromogranin A concentrations measured by radioimmunoassay in patients with small-cell lung carcinoma were compared with values from healthy adults and patients with non-small-cell lung carcinoma or chronic obstructive pulmonary disease. The mean (+/- SE) level was significantly higher (p less than or equal to 0.02) in patients with small-cell lung carcinoma (815 +/- 290 ng/mL, n = 46) than in normal controls (123 +/- 6 ng/mL, n = 20) or patients with chronic obstructive pulmonary disease (169 +/- 18 ng/mL, n = 39), lung adenocarcinoma (180 +/- 22, ng/mL, n = 62), large-cell lung carcinoma (183 +/- 23 ng/mL, n = 18), or lung epidermoid carcinoma (203 +/- 37 ng/mL, n = 78). The mean concentration in extensive-stage small-cell lung carcinoma (1155 +/- 449 ng/mL, n = 29) was significantly greater (p = 0.026) than in limited disease (234 +/- 56 ng/mL, n = 17). Elevated serum chromogranin A values were seen in 53% of patients with limited and 72% with extensive disease. Four patients originally classified as having non-small-cell lung carcinomas with raised chromogranin A levels were subsequently found to have mixed small-cell and non-small-cell tumors. Serum chromogranin A concentrations may be a useful marker of small-cell lung carcinoma disease activity.
- Subjects
CHROMOGRANINS; LUNG cancer; OBSTRUCTIVE lung diseases; NEUROENDOCRINE cells; COMPARATIVE studies; LUNG tumors; RESEARCH methodology; MEDICAL cooperation; NERVE tissue proteins; PROTEIN precursors; RADIOIMMUNOASSAY; REFERENCE values; RESEARCH; EVALUATION research; SMALL cell carcinoma
- Publication
Annals of Internal Medicine, 1986, Vol 105, Issue 5, p698
- ISSN
0003-4819
- Publication type
journal article
- DOI
10.7326/0003-4819-105-5-698