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- Title
Treatment of donor bone marrow with monoclonal anti-T-cell antibody and complement for the prevention of graft-versus-host disease. A prospective, randomized, double-blind trial.
- Authors
Mitsuyasu, Ronald T.; Champlin, Richard E.; Gale, Robert Peter; Ho, Winston G.; Lenarsky, Carl; Winston, Drew; Selch, Michael; Elashoff, Robert; Giorgi, Janis V.; Wells, John; Terasaki, Paul; Billing, Ronald; Feig, Stephen; Mitsuyasu, R T; Champlin, R E; Gale, R P; Ho, W G; Lenarsky, C; Winston, D; Selch, M
- Abstract
The effects of ex-vivo depletion of T lymphocytes from donor bone marrow using a monoclonal anti-T-cell antibody (CT-2) and complement on the outcome of allogeneic bone marrow transplantation was evaluated in a prospective, randomized, double-blind study of 40 patients with leukemia. Patients receiving T-cell-depleted bone marrow had a lower incidence of acute graft-versus-host disease than control patients (3 of 20 compared with 13 of 20; p = 0.004), and mortality due to acute graft-versus-host disease was reduced. Five patients in the T-cell-depletion group developed graft failure; all control patients had sustained engraftment (p less than 0.05). Clinically apparent relapse of leukemia occurred in 7 patients from the T-cell-depletion group and in 2 controls (p, not significant). Cytogenetic evidence of residual leukemia was also detected in the 5 patients with graft failure without overt relapse. Infections and overall survival were similar in the two groups. The effects of T-cell depletion on engraftment and recurrence of leukemia require further evaluation.
- Subjects
BONE marrow transplantation; T cells; GRAFT versus host disease prevention; LEUKEMIA treatment; THERAPEUTIC use of monoclonal antibodies; BONE marrow; CHRONIC diseases; CLINICAL trials; COMPARATIVE studies; COMPLEMENT (Immunology); IMMUNOSUPPRESSION; LEUKEMIA; LONGITUDINAL method; RESEARCH methodology; MEDICAL cooperation; RESEARCH; STATISTICAL sampling; SURVIVAL analysis (Biometry); DISEASE relapse; EVALUATION research; MYELOID leukemia; RANDOMIZED controlled trials; BLIND experiment; ACUTE diseases; LEUKOCYTE count; THERAPEUTICS
- Publication
Annals of Internal Medicine, 1986, Vol 105, Issue 1, p20
- ISSN
0003-4819
- Publication type
journal article
- DOI
10.7326/0003-4819-105-1-20