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- Title
Detection of Helicobacter pylori in the Bronchoalveolar Lavage of Patients with Lung Cancer Using Real-Time PCR.
- Authors
Samareh-Fekri, Mitra; Bajgani, Seyed Mehdi Hashemi; Shafahi, Ahmad; Asadi-Zarandi, Mahbobeh; Mollaie, Hamid; Paghalhe, Arshia Jamali
- Abstract
Background: Lungcancer isoneof themostcommoncauses of death worldwide. Althoughsmokingandenvironmental pollutants are the most important risk factors of lung cancer, the role of infectious causes should also be considered in the pathogenesis and progress of lung cancer. Objectives: This study examined the relationship between Helicobacter pylori and lung cancer through serology, real-time PCR, and urease tests. Methods: This descriptive cross-sectional study was conducted on 52 adult patients with lung cancerwhowere selected after having their history taken and being physically examined by a pulmonologist. Then, the patients underwent a bronchoscopy, a BAL, and biopsy sampling. A urease test was run for each biopsy sample, real-time PCR was used for each BAL sample, and H. pylori serology was used for each patient's serum. Results: The patients' average age was 60.65±9.15 years; 11.5% were female and 88.5% were male. The prevalence of H. pylori in lung cancer patients was 11.5% according to the BAL PCR test, 92.3% according to the serology test, and 3.8% according to the urease test. Conclusions: The results demonstrated an association between of lung cancer and H. Pylori infection via the hypothesis of direct damage and chronic inflammation through inhalation and aspiration and the systematic immune response induced by H. pylori colonization. Helicobacter pylori, together with a host's genetic predisposition and other environmental risk factors, could be attributed to the induction of lung cancer.
- Subjects
HELICOBACTER pylori; BRONCHOALVEOLAR lavage; LUNG cancer patients; HELICOBACTER pylori infections; POLYMERASE chain reaction
- Publication
Jundishapur Journal of Microbiology, 2016, Vol 9, Issue 11, p1
- ISSN
2008-3645
- Publication type
Article
- DOI
10.5812/jjm.32144