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- Title
Effect of chitosan coating on surgical sutures to strengthen the colonic anastomosis.
- Authors
Altınel, Yüksel; Soon Soup Chung; Okay, Güven; Uğraş, Nesrin; Işık, Ahmet Fatih; Öztürk, Ersin; Özgüç, Halil
- Abstract
BACKGROUND: We evaluated the feasibility of chitosan-coated sutures for intestinal anastomosis strength through wound-healing effect. METHODS: Vicryl and PDS sutures were coated with 2% chitosan. While laparotomy was applied to the first group, chitosan was applied in the peritoneal cavity in the second group. Then the following materials were applied to colon anastomosis, in order: Vicryl, PDS, chitosan-coated Vicryl, and chitosan-coated PDS sutures. On the 7th and 14th days, eight rats from each group were euthanized. RESULTS: The adhesion scores of chitosan and control groups were lower than the suture groups. The vascularization of Vicryl-chitosan was lower than PDS-chitosan on the 14th day (p=0.038). Fibroblast cells and vascularization of anastomosis with chitosan-coated Vicryl were lower than Vicryl and chitosan-coated PDS on the 14th day (p<0.05). The tensile strength of Vicryl-chitosan increased more than Vicryl in vitro (p<0.05) on the 14th and 7th days, but there was no difference in vivo. The tensile strength of PDS-chitosan decreased more than PDS on the 7th day in vivo (p<0.05). CONCLUSION: The chitosan-coating effect on the adhesion and reinforcement of anastomosis in some parts of Vicryl in vitro and PDS in vivo was slightly improved.
- Subjects
INTESTINAL surgery; ABDOMINAL surgery; TISSUE adhesions; BIOMEDICAL materials; FIBROBLASTS; INTESTINES; PERITONEUM; POLYSACCHARIDES; SUTURES; WOUND healing; SURGICAL anastomosis; TENSILE strength; IN vitro studies; IN vivo studies
- Publication
Turkish Journal of Trauma & Emergency Surgery / Ulusal Travma ve Acil Cerrahi Dergisi, 2018, Vol 24, Issue 5, p405
- ISSN
1306-696X
- Publication type
Article
- DOI
10.5505/tjtes.2018.59280