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- Title
The Clinical Characteristics of Children with Neuroblastoma.
- Authors
Sevinir, Betül; Demirkaya, Metin; Güler, Salih; Hekim, Hanife; Akaltun, Filiz
- Abstract
Introduction: The aim of this study was to evaluate the diagnostic characteristics of children with neuroblastoma (NBL). Materials and Methods: Hospital records were reviewed retrospectively. Age, symptoms and their durations, tumor site, stage and results of complete blood count, LDH and VMA were recorded. Statistical comparisons and calculations were made. Results: The mean age at diagnosis was 2.57±2.49 yrs (ranges 0-12). Of children, 89% were under 5 years and 32% were below 1 year. The most common tumor sites were abdomen [74.8%; (adrenal 66%), (non-adrenal 8.8%)], paraspinal region (12%), chest (7%) and pelvis (3.5%). Most of the tumors were in advanced stage (stage 1 and 2= 30.4 %, stage 3 and 4=13% and 46,1% and stage 4S=10.4%). The diagnosis was made from bone marrow cytology and increased VMA in 11% of the cases. VMA level was high in 83% of the patients. Median duration of symptoms was 6.5 weeks. The most frequent complaints were pallor, abdominal mass, abdominal pain and bone pain. Conclusions: NBL mainly involves young children. Clinical presentation varies with primary tumor site and dissemination. Anemia, abdominal and bone pain have diagnostic significance. (Journal of Current Pediatrics 2013; 11: 6-12)
- Publication
Journal of Current Pediatrics / Guncel Pediatri, 2013, Vol 11, Issue 1, p6
- ISSN
1304-9054
- Publication type
Journal Article
- DOI
10.4274/Jcp.11.02