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- Title
Tricyclic antidepressants. Prolonged plasma levels after overdose.
- Authors
Spiker, D G; Biggs, J T
- Abstract
Twenty-four patients hospitalized for overdose of a tricyclic antidepressant were monitored clinically, and serial plasma-drug measurements were taken for up to 144 hours. Six of 24 patients had maximum antidepressant plasma levels greater than or equal to 1,000 ng/ml, and their plasma levels at 96 hours ranged from 170 to 1,280 ng/ml. Patients ingesting substantial tricyclic overdoses may remain medically unstable for days. When high tricyclic levels persist, accurate psychiatric assessment is often impossible.
- Publication
JAMA: Journal of the American Medical Association, 1976, Vol 236, p1711
- ISSN
0098-7484
- Publication type
journal article