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- Title
Evaluation of vascular endothelial growth factor levels in rheumatoid arthritis patients, with and without joint swelling; a comparison with erythrocyte sedimentation rate, C-reactive protein, rheumatoid factor and anti-cyclic citruillnated protein.
- Authors
Gümüş, Alper; Coşkun, Cihan; Emre, Hümeyra Öztürk; Temel, Musa; İnal, Berrin Berçik; Seval, Hatice; Döventaş, Yasemin Erdoğan; Koldaş, Macit
- Abstract
Introduction: The aim of our study was to investigate the vascular endothelial growth factor levels in joint swelling-positive and joint swelling-negative rheumatoid arthritis patients and to then examine the relationship between conventional parameters such as the erythrocyte sedimentation rate and the levels of C-reactive protein, rheumatoid factor, and anti-cyclic citrullinated protein. Methods: Fifty-nine (52 women and seven men) rheumatoid arthritis patients and 25 (20 women and five men) healthy individuals volunteered for this study. The patient group was divided into two sub-groups based on whether or not they exhibited joint swelling. Results: The levels of vascular endothelial growth factor in the joint swelling-negative group were significantly different from those in the joint swelling-positive group, but they were not different from those in the control group (p=0.001 and p=0.72, respectively). We investigated the correlation between vascular endothelial growth factor and C-reactive protein levels (r=0.37, p=0.001). We also evaluated the diagnostic adequacy of vascular endothelial growth factor and created a ROC curve. The area under the curve was calculated to be 0.767. Conclusion: Vascular endothelial growth factor is an adequate diagnostic biomarker and can successfully be used to predict the occurrence of rheumatoid synovitis based on local inflammation.
- Subjects
VASCULAR endothelial growth factors; RHEUMATOID arthritis; C-reactive protein; LEUCOCYTES; BLOOD sedimentation; PATIENTS; PHYSIOLOGY
- Publication
Turkish Journal of Biochemistry / Turk Biyokimya Dergisi, 2018, Vol 43, Issue 1, p76
- ISSN
0250-4685
- Publication type
Article
- DOI
10.1515/tjb-2016-0308