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- Title
Therapy sculpts the complex interplay between cancer and the immune system during tumour evolution.
- Authors
Thol, Kerstin; Pawlik, Piotr; McGranahan, Nicholas
- Abstract
Cancer development is an evolutionary process. A key selection pressure is exerted by therapy, one of the few players in cancer evolution that can be controlled. As such, an understanding of how treatment acts to sculpt the tumour and its microenvironment and how this influences a tumour's subsequent evolutionary trajectory is critical. In this review, we examine cancer evolution and intra-tumour heterogeneity in the context of therapy. We focus on how radiotherapy, chemotherapy and immunotherapy shape both tumour development and the environment in which tumours evolve and how resistance can develop or be selected for during treatment.
- Subjects
IMMUNE system; TUMOR microenvironment; TUMORS; SCULPTURE; CARCINOGENESIS
- Publication
Genome Medicine, 2022, Vol 14, Issue 1, p1
- ISSN
1756-994X
- Publication type
Article
- DOI
10.1186/s13073-022-01138-3