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- Title
Unlocking the potential of RNA interference as a therapeutic tool.
- Authors
Ayers, Duncan; Day, Philip J. R.
- Abstract
The existence of an intrinsic biochemical pathway enabling specified regulation of gene expression was unheard of until the final years of the last decade. The identification of ribonucleic acid interference (RNAi) in mammalian cells has nowadays become of extreme importance in the field of functional genomics and translational medicine. The advent of RNAi technology has brought to the scientific research and pharmaceutical communities the ability to regulate expression of any desired gene in a reproducible manner. Consequently, such technology may be utilised in the design of novel therapeutics for clinical conditions having dys-regulated gene expression. Since most RNAi-based therapies in the drug development pipeline of pharmaceutical companies utilise short interfering RNA (siRNA), this review will focus on the role of siRNA in drug development.
- Subjects
GENE expression; DRUG development; GENETIC research; DRUG delivery devices; RNA; PHARMACEUTICAL industry
- Publication
Malta Medical Journal, 2009, Vol 21, Issue 3, p13
- ISSN
1813-3339
- Publication type
Article