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- Title
Analysis of confounding caused by creatinine and age in the correlation between soluble tumor necrosis factor α receptor 1 (sTNFR1) levels and estimated glomerular filtration rate (eGFR) in Colombian patients with type 2 diabetes.
- Authors
Poveda, Alejandro; Gómez-Banoy, Nicolás; Mockus, Ismena
- Abstract
Introduction. Tumor necrosis factor α (TNF-α) is a cytokine involved in inflammatory processes associated with type 2 diabetes mellitus (DM2). Although the correlation between soluble TNF-α receptor 1 (sTNFR1) levels and estimated glomerular filtration rate (eGFR) has been already described in Colombian population with DM2, the influence of sTNFR1 on eGFR in a model adjusted for age and creatinine level has not yet been evaluated. Objectives. To identify and evaluate the linear correlations between sTNFR1 levels, routine clinical variables, and eGFR in Colombian patients with DM2. Materials and methods. Cross-sectional study conducted in March 2020 in 69 patients with DM2 who were enrolled in the Program for the Prevention of Diabetes Complications and Dyslipidemias of the Faculty of Medicine of the Universidad Nacional de Colombia. Medical records were reviewed in order to obtain sociodemographic, anthropometric and clinical data. Serum sTNFR1 levels were determined by means of an ELISA test. A multiple linear regression model (stepwise regression) was performed to evaluate correlations between sTNFR1, clinical variables, and eGFR. Results. The final multiple linear regression model, which includes creatinine levels, sTNFR1 levels, and age, explained 72% of the variance of eGFR (p=0.023). Furthermore, sTNFR1 levels explained 20% of the variance of eGFR independently (standardized β coefficient: -0.2; 95%CI: [-0.008]-[-0.001]; p=0.02). Conclusion. In the final multiple linear regression model, an inversely proportional and statistically significant linear correlation was found between sTNFR1 levels and eGFR, independent of serum creatinine levels and age. Compared with age, sTNFR1 levels have a superior effect in terms of changes in eGFR.
- Subjects
UNIVERSIDAD Nacional de Colombia; TUMOR necrosis factors; GLOMERULAR filtration rate; TYPE 2 diabetes; EPIDERMAL growth factor receptors; CREATININE
- Publication
Revista Facultad de Medicina de la Universidad Nacional de Colombia, 2023, Vol 71, Issue 3, p1
- ISSN
0120-0011
- Publication type
Article
- DOI
10.15446/revfacmed.v71n3.107190