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- Title
Clinical and Virological Characteristics of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) B.1.617.2 (Delta) Variant: A Prospective Cohort Study.
- Authors
Park, Sunghee; Lim, So Yun; Kim, Ji Yeun; Park, Heedo; Lim, Joon Seo; Bae, Seongman; Kim, Jeonghun; Jung, Jiwon; Kim, Min Jae; Chong, Yong Pil; Choi, Sang Ho; Lee, Sang Oh; Kim, Yang Soo; Park, Man Seong; Kim, Sung Han
- Abstract
Background Data on the clinical and virological characteristics of the Delta variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are limited. This prospective cohort study compared the characteristics of the Delta variant to other variants. Methods Adult patients with mild coronavirus disease 2019 (COVID-19) who agreed to daily saliva sampling at a community isolation facility in South Korea between July and August 2021 were enrolled. Scores of 28 COVID-19-related symptoms were recorded daily. The genomic RNA and subgenomic RNA from saliva samples were measured by real-time reverse-transcription polymerase chain reaction (PCR). Cell cultures were performed on saliva samples with positive genomic RNA results. Results A total of 141 patients (Delta group, n = 108 [77%]; non-Delta group, n = 33 [23%]) were enrolled. Myalgia was more common in the Delta group than in the non-Delta group (52% vs 27%, P = .03). Total symptom scores were significantly higher in the Delta group between days 3 and 10 after symptom onset. Initial genomic RNA titers were similar between the 2 groups; however, during the late course of disease, genomic RNA titers were higher in the Delta group. Negative conversion of subgenomic RNA was slower in the Delta group (median 9 vs 5 days; P < .001). The duration of viral shedding in terms of positive viral culture was also longer in the Delta group (median 5 vs 3 days; P = .002). Conclusions COVID-19 patients infected with the Delta variant exhibited prolonged viable viral shedding with more severe symptoms than those infected with non-Delta variants.
- Subjects
SOUTH Korea; SALIVA analysis; COVID-19; SARS-CoV-2; GENETIC mutation; HEALTH facilities; CELL culture; RNA; COMPARATIVE studies; SYMPTOMS; GENOMICS; DESCRIPTIVE statistics; VIROLOGY; COVID-19 testing; ISOLATION (Hospital care); POLYMERASE chain reaction; LONGITUDINAL method
- Publication
Clinical Infectious Diseases, 2022, Vol 75, Issue 1, pe27
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1093/cid/ciac239