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- Title
Epidemiology, Risk Factors, and Outcomes of Respiratory Syncytial Virus Infections in Newborns in Bamako, Mali.
- Authors
Buchwald, Andrea G; Tamboura, Boubou; Tennant, Sharon M; Haidara, Fadima C; Coulibaly, Flanon; Doumbia, Moussa; Diallo, Fatoumata; Keita, Adama M; Sow, Samba O; Kotloff, Karen L; Levine, Myron M; Tapia, Milagritos D
- Abstract
Background Few studies describe the respiratory syncytial virus (RSV) burden in African populations, and most have utilized hospital-based surveillance. In Mali, no community-based studies exist of the incidence or epidemiology of RSV infection. This study provides the first estimates of RSV incidence in Mali. Methods In a cohort of infants enrolled in a clinical trial of maternal influenza vaccination, we estimate incidence of RSV-associated febrile illness in the first 6 months of life and identify risk factors for RSV infection and progression to severe disease. Infants (N = 1871) were followed from birth to 6 months of age and visited weekly to detect pneumonia and influenza-like illness. Baseline covariates were explored as risk factors for RSV febrile illness and RSV pneumonia or hospitalization. Results Incidence of RSV illness was estimated at 536.8 per 1000 person-years, and 86% (131/153) of RSV illness episodes were positive for RSV-B. RSV illness was most frequent in the fifth month of life and associated with having older mothers and with lower parity. The incidence of RSV-associated hospitalizations was 45.6 per 1000 person-years. Among infants with RSV illness, males were more likely to be hospitalized. The incidence of RSV pneumonia was 29 cases per 1000 person-years. Conclusions In the first 6 months of life, Malian infants have a high incidence of RSV illness, primarily caused by RSV-B. Prevention of early RSV will require passive protection via maternal immunization in pregnancy. Mali is the first country where RSV-B has been identified as the dominant subtype, with potential implications for vaccine development.
- Subjects
MALI; AGE distribution; FEVER; HOSPITAL care; INFLUENZA; MOTHERS; PUBLIC health surveillance; RISK assessment; SEX distribution; VIRAL pneumonia; DISEASE incidence; PARITY (Obstetrics); DISEASE progression; DESCRIPTIVE statistics; RESPIRATORY syncytial virus infections; DISEASE complications; DISEASE risk factors; CHILDREN
- Publication
Clinical Infectious Diseases, 2020, Vol 70, Issue 1, p59
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1093/cid/ciz157