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- Title
High prevalence of hepatitis C virus infection and predominance of genotype 4 in rural gabon.
- Authors
Ndong-Atome, G.R.; Makuwa, M.; Ouwe-Missi-Oukem-Boyer, O.; Pybus, O.G.; Branger, M.; Le Hello, S.; Boye-Cheik, S.B.; Brun-Vezinet, F.; Kazanji, M.; Roques, P.; Bisser, S.
- Abstract
Hepatitis C (HCV) molecular epidemiology is documented poorly in central African countries. In response to this, a population-based study of 319 consenting adults resident in a remote village of Gabon was undertaken (mean age: 38 years; age range: 13-85+; sex ratio: 0.74). Screening for anti-HCV antibodies was performed using ELISA and recombinant immunoblot assay. Seropositive samples were assessed further with viral load and genotyping techniques. Sixty-six (20.7%) individuals were HCV seropositive. Viral loads ranged from 600 to 24.9 million IU/ml (median: 372,500). Seroprevalence and viral loads increased significantly with age ( P < 10−5 and P < 0.003, respectively). HCV sequences of the 5′UTR genome region were obtained from 60 (90.9%) samples and NS5B region sequences were obtained from 22 (36.6%) samples. All strains belonged to subtypes of genotype 4: 4e (72.7%), 4c (13.6%), 4p (4.5%), 4r (4.5%) and one unclassified genotype 4 strain. Evolutionary analysis of the subtype 4e sequences indicates a period of raised transmission during the early twentieth century. J. Med. Virol. 80:1581-1587, 2008. © 2008 Wiley-Liss, Inc.
- Publication
Journal of Medical Virology, 2008, Vol 80, Issue 9, p1581
- ISSN
0146-6615
- Publication type
Article
- DOI
10.1002/jmv.21252