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- Title
Involved field radiotherapy (IFRT) versus elective nodal irradiation (ENI) for locally advanced non-small cell lung cancer: a meta-analysis of incidence of elective nodal failure (ENF).
- Authors
Ruijian Li; Liang Yu; Sixiang Lin; Lina Wang; Xin Dong; Lingxia Yu; Weiyi Li; Baosheng Li
- Abstract
Background and purpose: The use of involved field radiotherapy (IFRT) has generated concern about the increasing incidence of elective nodal failure (ENF) in contrast to elective nodal irradiation (ENI). This meta-analysis aimed to provide more reliable and up-to-date evidence on the incidence of ENF between IFRT and ENI. Materials and methods: We searched three databases for eligible studies where locally advanced non-small cell lung cancer (NSCLC) patients received IFRT or ENI. Outcome of interest was the incidence of ENF. The fixed-effects model was used to pool outcomes across the studies. Results: There were 3 RCTs and 3 cohort studies included with low risk of bias. There was no significant difference in incidence of ENF between IFRT and ENI either among RCTs (RR = 1.38, 95 % CI: 0.59-3.25, p = 0.46) or among cohort studies (RR = 0.99, 95 % CI: 0.46-2.10, p = 0.97). There was also no significant difference in incidence of ENF between IFRT and ENI when RCTs and cohort studies were combined (RR = 1.15, 95 % CI: 0.65-2.01, p = 0.64). I2 of test for heterogeneity was 0 %. Conclusion: This meta-analysis provides more reliable and stable evidence that there is no significant difference in incidence of ENF between IFRT and ENI.
- Subjects
RADIOTHERAPY; SMALL cell lung cancer; BRONCHIAL carcinoma; META-analysis; LUNG cancer; CANCER treatment
- Publication
Radiation Oncology, 2016, Vol 11, p1
- ISSN
1748-717X
- Publication type
Article
- DOI
10.1186/s13014-016-0698-3