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- Title
Pooled analysis of nivolumab treatment in patients with recurrent/metastatic squamous cell carcinoma of the head and neck in the United States and Germany.
- Authors
Singh, Prianka; McDonald, Laura; Waldenberger, Daniela; Welslau, Manfred; von der Heyde, Eyck; Gauler, Thomas; Dietz, Andreas
- Abstract
Background: In the Phase‐III clinical trial, CheckMate 141, nivolumab significantly improved survival versus standard of care in patients with platinum‐refractory recurrent/metastatic squamous cell carcinoma of the head and neck (R/M SCCHN). Methods: This pooled analysis investigated the real‐world effectiveness of nivolumab, following prior platinum‐based therapy, in patients with R/M SCCHN from the United States (US) Flatiron Health database and German HANNA prospective observational study. Results: Overall, 782 patients (56% US; 44% Germany) were included. Median overall survival (OS) was 8.71 months, and progression‐free survival was 4.11 months. Eastern Cooperative Oncology Group Performance Status 0 or 1, platinum sensitivity, and older age were associated with longer OS, in which number of prior lines of therapy had no significant effect. Conclusion: These findings demonstrate survival benefits of nivolumab in patients with R/M SCCHN in the real‐world setting. The observed real‐world effectiveness of nivolumab aligns with the efficacy of nivolumab in CheckMate 141.
- Subjects
GERMANY; UNITED States; NIVOLUMAB; SQUAMOUS cell carcinoma; OVERALL survival; SURVIVAL rate; NECK
- Publication
Head & Neck, 2021, Vol 43, Issue 11, p3540
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.26853